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How G-CSF Can Help Manage Cyclic Neutropenia
Published: Sep 27, 2023
Granulocyte colony-stimulating factor (G-CSF) is a key treatment for cyclic neutropenia, helping to alleviate symptoms and reduce infection risk. Learn how it works and its benefits.
What is G-CSF?
G-CSF is a treatment that stimulates neutrophil production, shortening the period of neutropenia. It is well-tolerated and effective in reducing infection risks, making it a vital therapy for those with cyclic neutropenia. Available as filgrastim or pegfilgrastim, it is administered by subcutaneous injection.
How Does G-CSF Treatment Work?
Patients receive G-CSF through regular injections, typically daily or thrice weekly, to maintain neutrophil counts. The goal is to keep counts above 500/microL to prevent severe infections and improve quality of life. Continuous administration is preferred over trying to match neutropenic cycles.
Managing Side Effects
While G-CSF is generally safe, some patients may experience mild musculoskeletal pain. Monitoring and adjusting the dose can alleviate side effects, ensuring treatment remains effective. Regular blood tests help in tailoring the therapy to individual needs.
Frequently Asked Questions
It's used to increase neutrophil counts in cyclic neutropenia.
It's given daily or thrice weekly by injection.
Side effects are mild, like musculoskeletal pain.
Yes, it's safe with regular monitoring and adjustments.
The Bottom Line
G-CSF is a crucial therapy for managing cyclic neutropenia effectively.
References
- Dale DC, Bolyard A, Marrero T, et al. Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia. N Engl J Med 2017; 377:2290.
- Hammond WP 4th, et al. Treatment of cyclic neutropenia with granulocyte colony-stimulating factor. N Engl J Med 1989; 320:1306.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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