How Do Doctors Diagnose Anemia of Chronic Disease?
Published: Sep 18, 2024
Diagnosing anemia of chronic disease involves a series of tests. Let's explore what these tests reveal and how they help.
Contents
What Tests Are Used?
Diagnosing anemia of chronic disease (ACD) typically starts with a complete blood count (CBC) to check levels of red blood cells, hemoglobin, and other components. Iron studies, including serum ferritin and transferrin saturation, help differentiate ACD from iron deficiency anemia. Additional tests for inflammation, like C-reactive protein (CRP), might also be conducted.
Interpreting the Results
ACD is often characterized by normal to high ferritin levels with low serum iron and transferrin saturation. This pattern helps distinguish ACD from iron deficiency, where ferritin is low. Elevated markers of inflammation, such as CRP, further support the diagnosis of ACD.

Why Testing Is Important
Testing is crucial as ACD symptoms can mimic other types of anemia. Accurate diagnosis ensures that the underlying cause is identified and treated effectively. This helps avoid unnecessary treatments and focuses on managing the root problem.
Frequently Asked Questions
CBC, iron studies, and inflammation tests are used.
ACD has normal/high ferritin, unlike iron deficiency.
It ensures accurate diagnosis and appropriate treatment.
Key Takeaways
Tests are vital for distinguishing ACD from other anemias and guiding treatment.
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References
Thomas DW, Hinchliffe RF, Briggs C, et al. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haematol 2013; 161:639.
Ginzburg YZ. New diagnostic tools for delineating iron status. Hematology Am Soc Hematol Educ Program 2019; 2019:327.
Always discuss health information with your healthcare provider.