Guidelines for Managing Diabetic Neuropathy Pain
Published: Sep 02, 2023
Managing diabetic neuropathy pain effectively requires following established guidelines. Discover the recommended approaches and treatments to achieve the best outcomes.
Contents
Initial Treatment Recommendations
The first step in managing diabetic neuropathy pain involves using medications with proven efficacy. Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine and venlafaxine, as well as tricyclic antidepressants and gabapentinoid antiseizure medications, are commonly recommended. These guidelines ensure patients receive treatments backed by scientific research.
Alternative Options for Pain Relief
For patients who do not respond to initial treatments, alternative approaches are available. Options include topical treatments like capsaicin cream and lidocaine patches, as well as non-drug therapies such as acupuncture and electrical nerve stimulation. These alternatives provide additional avenues for relief when first-line therapies are insufficient.

Caution with Opioids
Opioids are generally not recommended for managing diabetic neuropathy pain due to potential risks like addiction and overdose. While some guidelines mention opioids as a last-resort option, safer alternatives are preferred. Patients should be aware of the risks and exhaust other treatments before considering opioids.
Frequently Asked Questions
SNRIs, tricyclic antidepressants, and gabapentinoids are recommended.
Alternative therapies like capsaicin and acupuncture can be tried.
Generally not, due to risks of addiction and overdose.
The Bottom Line
Following guidelines ensures safe and effective management of diabetic neuropathy pain.
References
- Price R, Smith D, Franklin G, et al. Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary: Report of the AAN Guideline Subcommittee. Neurology 2022; 98:31.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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