Differential Diagnosis for Ganglion Cysts: What Else Could It Be?
Published: Aug 22, 2024
Not every lump is a ganglion cyst. Discover other conditions that might mimic these common swellings.
Contents
Common Mimickers
Conditions like tenosynovial giant cell tumors and epidermoid cysts can resemble ganglion cysts. These are usually firm, fixed swellings that don't transilluminate like ganglion cysts.
Skin Lesions and Nodules
Lipomas and rheumatoid nodules are examples of skin lesions that could be mistaken for ganglion cysts. Unlike cysts, lipomas are soft and painless, while rheumatoid nodules are firm and occur with arthritis.

Infections and Gout
Infectious tenosynovitis and tophi from gout are conditions that can present with nodules. Infections usually cause swelling and tenderness, whereas tophi are firm nodules related to uric acid deposits.
Frequently Asked Questions
Tenosynovial giant cell tumors and epidermoid cysts.
Yes, lipomas and rheumatoid nodules can appear similar.
Infectious tenosynovitis can mimic cysts with swelling.
Yes, tophi from gout can resemble cysts.
Consider All Options
Understanding other potential diagnoses ensures better treatment decisions.
References
- Crosby SN, Alamanda VK, Weikert DR, Holt GE. Avoiding unplanned resections of wrist sarcomas: an algorithm for evaluating dorsal wrist masses. Am J Orthop (Belle Mead NJ) 2013; 42:401.
- Hsu CS, Hentz VR, Yao J. Tumours of the hand. Lancet Oncol 2007; 8:157.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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