Cushing Syndrome Symptoms: Are You Missing the Signs?
Published: Nov 27, 2023
Cushing syndrome can present a wide array of symptoms, often mistaken for other conditions. Learn how to spot the signs that truly matter.
Contents
Recognizing the Red Flags
The symptoms of Cushing syndrome can be quite varied, but some are more indicative than others. Key signs include rapid weight gain, particularly around the face and abdomen, the development of purple stretch marks, and muscle weakness. These symptoms often appear together, increasing in severity over time.
The Skin's Story
Cushing syndrome can cause significant changes to the skin. Patients may experience easy bruising, purple striae, and skin thinning. These dermatologic changes are less common in the general population, making them more suggestive of Cushing syndrome.

Metabolic Mayhem
Cushing syndrome can disrupt the body's metabolism, leading to glucose intolerance and even diabetes. This is due to cortisol's effect on blood sugar levels and insulin resistance. Individuals with poorly controlled diabetes and obesity should consider screening for Cushing syndrome.
Frequently Asked Questions
Key symptoms include weight gain, purple stretch marks, and muscle weakness.
It causes easy bruising, purple striae, and skin thinning.
Yes, it can lead to glucose intolerance and diabetes.
Consult a healthcare provider for further evaluation.
Key Takeaways
Identifying the symptoms of Cushing syndrome early can help manage its impact on health.
References
- Ross EJ, Linch DC. Cushing's syndrome--killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet 1982; 2:646.
- Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2008; 93:1526.
- Nieman LK. Cushing's syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol 2015; 173:M33.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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