Could These Tests Reveal the Secrets of Cushing Syndrome?

The Role of Cortisol in Diagnosing Cushing Syndrome

Cortisol, a hormone, plays a crucial role in our body's stress response. In Cushing syndrome, cortisol levels are abnormally high. Tests like urine free cortisol and bedtime salivary cortisol help determine these levels. By measuring cortisol consistently over weeks, doctors can confirm a diagnosis of hypercortisolism, a key step in identifying Cushing syndrome.

ACTH: The Hormone Detective

ACTH, another hormone, helps distinguish between ACTH-dependent and independent forms of Cushing syndrome. Measuring plasma ACTH can indicate if the condition stems from a pituitary or adrenal source. Values below 5 pg/mL suggest ACTH-independent Cushing syndrome, while values above 20 pg/mL point to ACTH-dependent conditions.

Advanced Diagnostic Tools

Beyond hormone levels, doctors use imaging tests like CT and MRI to locate tumors causing excess cortisol production. Biochemical tests such as the dexamethasone suppression test can further clarify the source of ACTH. These tests, while complex, are essential for diagnosing and managing Cushing syndrome effectively.

Frequently Asked Questions

Key Takeaways

Accurate testing is crucial for diagnosing and treating Cushing syndrome.

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