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Could These Tests Reveal the Secrets of Cushing Syndrome?
Published: May 22, 2024
Discover how doctors use various tests to uncover the mystery behind Cushing syndrome and its symptoms.
The Role of Cortisol in Diagnosing Cushing Syndrome
Cortisol, a hormone, plays a crucial role in our body's stress response. In Cushing syndrome, cortisol levels are abnormally high. Tests like urine free cortisol and bedtime salivary cortisol help determine these levels. By measuring cortisol consistently over weeks, doctors can confirm a diagnosis of hypercortisolism, a key step in identifying Cushing syndrome.
ACTH: The Hormone Detective
ACTH, another hormone, helps distinguish between ACTH-dependent and independent forms of Cushing syndrome. Measuring plasma ACTH can indicate if the condition stems from a pituitary or adrenal source. Values below 5 pg/mL suggest ACTH-independent Cushing syndrome, while values above 20 pg/mL point to ACTH-dependent conditions.
Advanced Diagnostic Tools
Beyond hormone levels, doctors use imaging tests like CT and MRI to locate tumors causing excess cortisol production. Biochemical tests such as the dexamethasone suppression test can further clarify the source of ACTH. These tests, while complex, are essential for diagnosing and managing Cushing syndrome effectively.
Frequently Asked Questions
It's a test measuring cortisol levels in urine over 24 hours to assess cortisol production.
ACTH levels help determine if the syndrome is ACTH-dependent or independent.
CT and MRI scans are used to locate tumors causing excess cortisol.
It evaluates how cortisol levels respond to the steroid dexamethasone.
The Bottom Line
Accurate testing is crucial for diagnosing and treating Cushing syndrome.
References
- Raff H, Findling JW. A new immunoradiometric assay for corticotropin. Clin Chem 1989; 35:596.
- Frete C, et al. Non-invasive Diagnostic Strategy in ACTH-dependent Cushing's Syndrome. J Clin Endocrinol Metab 2020; 105.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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