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Can These Treatments Slow Cognitive Decline in Parkinson's?
Published: Dec 29, 2023
While there's no cure for cognitive decline in Parkinson's, certain treatments may offer some relief and improve quality of life.
Cholinesterase Inhibitors
Cholinesterase inhibitors are suggested for patients with Parkinson's disease dementia (PDD). These medications can modestly improve cognition, though they may come with side effects like nausea and worsened tremors.
Memantine's Role
Memantine, another medication, has shown mixed results in PD patients. While it may improve some cognitive functions, it can also cause hallucinations in some cases, necessitating careful monitoring.
Managing Psychosis
Antiparkinsonian medications can lead to visual hallucinations and delusions, especially in advanced stages. Adjusting these medications can alleviate symptoms, but may require the cautious use of antipsychotic drugs.
Frequently Asked Questions
Yes, they can offer modest cognitive improvement.
Memantine's effects are mixed, with some risk of hallucinations.
Yes, but it may require careful use of antipsychotics.
Possible side effects include nausea and worsened tremors.
The Bottom Line
While no treatment stops cognitive decline in PD, some therapies can improve symptoms and quality of life.
References
- Emre M, Aarsland D, Albanese A, et al. Rivastigmine for dementia associated with Parkinson's disease. N Engl J Med 2004; 351:2509.
- Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol 2009; 8:613.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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