Can Medication Help with Orthostatic Hypotension?
Published: Apr 15, 2024
For those struggling with orthostatic hypotension, medications can offer relief when lifestyle changes aren't enough. Discover which medications might work for you.
Contents
Fludrocortisone: Volume Booster
Fludrocortisone is a medication that helps your body retain salt and water, which increases your blood volume and pressure. It's often used when increasing salt and water intake isn't enough. Though effective, it can have side effects like swelling and high blood pressure when lying down, so it's important to use it under medical supervision.
Midodrine: Raising Resistance
Midodrine works by tightening blood vessels, which increases blood pressure. It's especially helpful for people whose symptoms don't improve with salt and water alone. However, it should not be taken close to bedtime, as it can cause high blood pressure when lying down. Common side effects include goosebumps, itching, and stomach discomfort.

Droxidopa: A Modern Solution
Droxidopa is a newer medication that helps your body produce norepinephrine, a chemical that raises blood pressure. It's particularly useful for patients with neurological issues. The dosage can vary, and it's essential to monitor blood pressure regularly to avoid potential side effects like headaches and nausea.
Frequently Asked Questions
It helps retain salt and water to increase blood volume and pressure.
It tightens blood vessels to raise blood pressure.
Yes, it's effective, especially for those with neurological conditions.
Yes, side effects can include headaches, nausea, and high blood pressure when lying down.
The Bottom Line
Medications can be effective but should be used with caution and regular monitoring.
References
- Isaacson S, Shill HA, Vernino S, et al. Safety and Durability of Effect with Long-Term, Open-Label Droxidopa Treatment in Patients with Symptomatic Neurogenic Orthostatic Hypotension (NOH303). J Parkinsons Dis 2016; 6:751.
- Hauser RA, Hewitt LA, Isaacson S. Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson's disease (NOH306A). J Parkinsons Dis 2014; 4:57.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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