Breast Cancer: What You Need to Know
Published: Sep 06, 2023
Breast cancer is the most common cancer affecting women worldwide, and understanding its causes is crucial. This article breaks down the factors influencing breast cancer risk and the biology behind it.
Contents
Understanding Breast Cancer Risk
Breast cancer risk is influenced by both natural and external hormone factors. Natural factors include early menstruation, having no children, or having a first child at an older age. External factors can be hormone therapies used during menopause. These elements affect the breast's development and hormone exposure, which can increase cancer risk.
Breast Anatomy and Cancer Development
The breast comprises skin, tissue, and ducts that connect to the nipple. Cancer often originates in the terminal ductal lobular unit (TDLU), which is the functional unit of the breast. Differences in these structures can influence the likelihood of developing cancer.

Hormones and Breast Cancer
Both estrogen and progesterone play significant roles in breast tissue development and cancer risk. Estrogen promotes cell growth, and when combined with progesterone, it influences breast development. Hormone receptors in the breast can make it more susceptible to cancer when exposed to these hormones.
Frequently Asked Questions
Factors like early menstruation, late childbirth, and hormone therapies increase risk.
Cancer often begins in the breast's functional units called TDLUs.
Yes, hormones like estrogen and progesterone increase risk by promoting cell growth.
Key Takeaways
Understanding breast cancer risk factors helps in early detection and prevention strategies.
References
- Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61:212.
- Russo IH, Russo J. Mammary gland neoplasia in long-term rodent studies. Environ Health Perspect 1996; 104:938.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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