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Breaking Down Biologic Therapies: The Latest Treatments for Crohn's Disease
Published: Nov 24, 2023
Biologic therapies have revolutionized the treatment of Crohn's disease, offering hope to many patients who haven't responded well to traditional medications. These advanced drugs target specific parts of the immune system to reduce inflammation and promote healing.
What Are Biologic Therapies?
Biologic therapies are complex proteins made from living organisms. Unlike traditional drugs, they're designed to target specific molecules in the body that play a role in inflammation. For Crohn's disease, biologics typically work by blocking inflammatory substances like tumor necrosis factor (TNF) or interleukins.
Types of Biologics for Crohn's
Several types of biologics are used to treat Crohn's disease. Anti-TNF drugs like infliximab and adalimumab were the first biologics approved for Crohn's. Newer options include ustekinumab, which targets interleukins, and vedolizumab, which works in the gut to reduce inflammation. Each type works slightly differently and may be more effective for certain patients.
How Are Biologics Given?
Most biologics are given by injection or intravenous infusion. The frequency can vary from every few weeks to every few months, depending on the specific drug. Some biologics can be self-administered at home, while others require visits to a healthcare facility. Your doctor will determine the best administration method and schedule for your situation.
Potential Benefits and Risks
Biologic therapies can be highly effective at reducing inflammation, healing the intestines, and maintaining remission in Crohn's disease. They may work when other treatments have failed. However, they can also have side effects, including an increased risk of infections. It's important to discuss the potential benefits and risks with your doctor before starting biologic therapy.
Frequently Asked Questions
No, but they can induce and maintain remission.
Some patients see improvement in weeks, others in months.
Possibly, but always consult your doctor first.
Some are considered safe, but discuss with your doctor.
Treatment duration varies; your doctor will advise.
A Promising Option
While not suitable for everyone, biologic therapies offer a powerful tool in the fight against Crohn's disease.
References
- Feuerstein JD, et al. AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease. Gastroenterology. 2021;160(7):2496-2508.
- Lichtenstein GR, et al. ACG Clinical Guideline: Management of Crohn's Disease in Adults. Am J Gastroenterol. 2018;113(4):481-517.
- Ford AC, et al. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):644-659.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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