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Contents
  • What Are BRCA Genes?
  • How BRCA Mutations Affect Cancer Risk
  • Testing for BRCA Mutations
  • Managing BRCA-Related Cancer Risk

BRCA Mutations and Breast Cancer: What You Need to Know

BRCA Mutations and Breast Cancer: What You Need to Know

Genes and Cancer Risk

BRCA mutations are genetic changes that can significantly increase a person's risk of developing breast cancer. Understanding these mutations is crucial for those with a family history of the disease.
Contents
  • What Are BRCA Genes?
  • How BRCA Mutations Affect Cancer Risk
  • Testing for BRCA Mutations
  • Managing BRCA-Related Cancer Risk

What Are BRCA Genes?

BRCA1 and BRCA2 are genes that help repair damaged DNA and suppress tumor growth. When these genes have mutations, they can't function properly, leading to an increased risk of certain cancers. Think of BRCA genes as the body's natural cancer-fighting superheroes – mutations weaken their powers.

How BRCA Mutations Affect Cancer Risk

Women with BRCA mutations have a much higher lifetime risk of developing breast cancer compared to the general population. The risk can be as high as 70% by age 80. These mutations also increase the risk of ovarian cancer and, to a lesser extent, other cancers. Men with BRCA mutations have an increased risk of breast and prostate cancers.
BRCA1 and BRCA2 gene mutations significantly increase the risk of breast and ovarian cancers by impairing DNA repair mechanisms.

Testing for BRCA Mutations

Genetic testing can identify BRCA mutations. This is typically recommended for people with a strong family history of breast or ovarian cancer, especially at young ages. The test involves a simple blood draw or saliva sample. Genetic counseling is an important part of the process to help understand the results and implications.

Managing BRCA-Related Cancer Risk

If you have a BRCA mutation, there are several options to manage your cancer risk. These include more frequent cancer screenings, preventive medications, and risk-reducing surgeries like mastectomy or ovary removal. The right approach depends on your personal preferences and family planning goals. Your healthcare team will help you make informed decisions.

FAQs

Can BRCA mutations skip generations?

Yes, BRCA mutations can be inherited from either parent and may skip generations.

Do all BRCA mutation carriers develop cancer?

No, having a mutation increases risk but doesn't guarantee cancer will develop.

Can men have BRCA mutations?

Yes, men can carry and pass on BRCA mutations, and have increased cancer risks.

Does insurance cover BRCA testing?

Many insurance plans cover testing for high-risk individuals, but check your specific policy.

Can BRCA mutations affect cancer treatment?

Yes, some treatments may be more effective for cancers related to BRCA mutations.

Knowledge is Power

Understanding your BRCA status can empower you to make informed decisions about your health and cancer prevention strategies.
Concerned about your BRCA status or family history of breast cancer? Start a conversation with Doctronic to learn more about genetic testing and risk management.
Additional References
  1. National Cancer Institute. BRCA Mutations: Cancer Risk and Genetic Testing. https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet
  2. American Cancer Society. Breast Cancer Risk Factors You Cannot Change. https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/breast-cancer-risk-factors-you-cannot-change.html
  3. Breastcancer.org. BRCA1 & BRCA2 Genes: Risk for Breast and Ovarian Cancer. https://www.breastcancer.org/risk/factors/genetics
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.