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Beyond Skin Deep: When Itching Signals Systemic Disease
Published: Jan 08, 2024
Itching isn't always just a skin problem. Sometimes, it can be a sign of an underlying systemic disease affecting other parts of your body.
Liver and Kidney Connections
Chronic kidney disease and liver disorders like primary biliary cholangitis can cause persistent itching. In kidney disease, itching often worsens during or after dialysis. Liver-related itching typically starts on the palms and soles before becoming more widespread.
Blood and Cancer Concerns
Certain blood disorders and cancers can manifest with itching as an early symptom. Hodgkin lymphoma, polycythemia vera, and other hematologic malignancies may cause intense itching long before other symptoms appear. This underscores the importance of investigating persistent, unexplained itching.
Hormonal and Metabolic Links
Thyroid disorders and diabetes can also trigger itching. Hyperthyroidism often causes generalized itching, while diabetes-related itching is usually localized. These conditions highlight how hormonal imbalances and metabolic changes can affect skin sensations.
Frequently Asked Questions
Yes, in some cases itching can precede other symptoms.
If itching persists for more than six weeks, consult a healthcare provider.
Generalized itching without a rash can be a red flag for systemic issues.
Don't Ignore the Itch
While not all chronic itching indicates a serious condition, it's a symptom that shouldn't be ignored or dismissed.
References
- Yosipovitch G. Chronic pruritus: a paraneoplastic sign. Dermatol Ther 2010; 23:590.
- Wang H, Yosipovitch G. New insights into the pathophysiology and treatment of chronic itch in patients with end-stage renal disease, chronic liver disease, and lymphoma. Int J Dermatol 2010; 49:1.
- Etter L, Myers SA. Pruritus in systemic disease: mechanisms and management. Dermatol Clin 2002; 20:459.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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