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Aspirin and Clopidogrel: The Dynamic Duo for Stroke Prevention?
Published: May 09, 2024
Aspirin and clopidogrel are often used together to prevent strokes, but why is this combination so effective? Let's uncover the science behind it.
How Aspirin Works
Aspirin is a widely used antiplatelet drug that prevents blood clots by inhibiting the enzyme that makes platelets sticky. This helps reduce the risk of a stroke by keeping blood flowing smoothly through the arteries. It's often the first choice for those with low-risk TIAs.
Clopidogrel's Role
Clopidogrel is another antiplatelet medication that works by blocking a specific receptor on platelets, preventing them from clumping together. When used alongside aspirin, it provides an added layer of protection, particularly for patients with high-risk TIAs or minor strokes.
Combining Forces: Dual Antiplatelet Therapy
The combination of aspirin and clopidogrel is known as Dual Antiplatelet Therapy (DAPT). Research shows that DAPT is effective in reducing stroke risk when started promptly after a TIA or minor stroke. However, the therapy is typically limited to 21 days due to increased bleeding risk.
Frequently Asked Questions
Together, they provide stronger prevention against blood clots.
For low-risk cases, yes, but high-risk patients may need both drugs.
Increased bleeding risk, limiting its use to short-term therapy.
Typically for 21 days after a TIA or minor stroke.
Key Takeaways
Aspirin and clopidogrel together can be powerful in stroke prevention but require careful management.
References
- Kleindorfer DO, Towfighi A, Chaturvedi S, et al. Stroke 2021; 52:e364.
- Johnston SC, Nguyen-Huynh MN, Schwarz ME, et al. Ann Neurol 2006; 60:301.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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