Aromatase Inhibitors: The Secret Weapon Against Breast Cancer
Published: May 06, 2024
Aromatase inhibitors are a game-changer in treating hormone receptor-positive breast cancer in postmenopausal women. Discover why they're so effective.
Contents
How Aromatase Inhibitors Work
Aromatase inhibitors work by blocking the enzyme aromatase, which converts androgens into estrogens. This process reduces estrogen levels, which is crucial because many breast cancers grow in response to estrogen.
Popular Aromatase Inhibitors
Common aromatase inhibitors include anastrozole, letrozole, and exemestane. Each has been shown to reduce the risk of cancer recurrence and is generally well-tolerated, though they do have some side effects like joint pain and bone loss.

Comparing With Other Treatments
Compared to tamoxifen, aromatase inhibitors often offer better outcomes in reducing cancer recurrence. However, they are only active in postmenopausal women, so tamoxifen remains a valuable alternative for those who cannot tolerate aromatase inhibitors.
Frequently Asked Questions
They reduce estrogen levels to prevent cancer growth.
Anastrozole, letrozole, and exemestane are popular options.
They often offer better outcomes but have different side effects.
No, they are only effective for postmenopausal women.
Key Takeaways
Aromatase inhibitors are a powerful tool against breast cancer in postmenopausal women.
Explore if aromatase inhibitors are right for you by consulting with Doctronic!Related Articles
References
Smith I, Yardley D, Burris H, et al. Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation (FACE) Trial. J Clin Oncol 2017; 35:1041.
Henry NL, Azzouz F, Desta Z, et al. Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J Clin Oncol 2012; 30:936.
Always discuss health information with your healthcare provider.