Contents
Are You at Risk for Essential Thrombocythemia?
Published: Sep 11, 2023
Understanding the risk factors for Essential Thrombocythemia (ET) can help in early detection and management. Discover who is more likely to develop this condition and how.
Genetic Factors
ET is often linked to genetic mutations, particularly in the JAK2, CALR, and MPL genes. These mutations can be somatically acquired, meaning they occur after birth, and they play a significant role in the development of the condition. Identifying these mutations is crucial for diagnosis and understanding an individual's risk.
Demographic Influences
The likelihood of developing ET varies based on age, sex, and race. It is more common in individuals over 60 and affects women more frequently than men. Certain ethnic groups also show different incidence rates, with Black Americans having a higher occurrence than White Americans.
Lifestyle and Health Factors
While genetic factors are significant, lifestyle and other health conditions can influence ET risk. Factors such as cardiovascular health, smoking, and diabetes can impact the severity and complications of ET. Regular health check-ups can help manage these risks.
Frequently Asked Questions
Mutations in JAK2, CALR, and MPL genes are linked to ET.
People over 60 years old are most affected.
Yes, lifestyle factors like smoking and diabetes can affect ET risk.
Key Takeaways
Knowing your risk factors is the first step towards managing ET effectively.
References
- Srour SA, Devesa SS, Morton LM, et al. Incidence and patient survival of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms in the United States, 2001-12. Br J Haematol 2016; 174:382.
- Rumi E, Cazzola M. Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms. Blood 2017; 129:680.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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