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Are Thiazolidinediones a Good Bet for Preventing Diabetes?
Published: Sep 02, 2024
While lifestyle changes are key, some have looked to thiazolidinediones for diabetes prevention. Let's explore if they are worth the risks.
Prevention Potential
Thiazolidinediones have shown some promise in delaying the onset of type 2 diabetes in high-risk individuals. By improving insulin sensitivity, they can reduce blood sugar levels and delay the diagnosis of diabetes. However, the benefits must be weighed against their potential side effects.
The Risks Involved
Despite their potential, thiazolidinediones are not recommended for diabetes prevention due to their side effects. These include weight gain, fluid retention, and increased risk of heart failure. The potential harms may outweigh the benefits of delaying diabetes.
Focus on Lifestyle
Experts suggest focusing on lifestyle changes like diet and exercise for diabetes prevention. These methods are effective and come without the side effects associated with thiazolidinediones. In some cases, metformin is considered for prevention alongside lifestyle interventions.
Frequently Asked Questions
They can delay diabetes onset but are not recommended for prevention.
Side effects include weight gain and heart failure risk.
Lifestyle changes like diet and exercise are recommended.
Yes, metformin can be used alongside lifestyle changes.
No, they have risks that make them unsuitable for everyone.
The Bottom Line
Thiazolidinediones are not the ideal choice for diabetes prevention due to their risks.
References
- DeFronzo RA, Tripathy D, Schwenke DC, et al. Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med 2011; 364:1104.
- Inzucchi SE, Viscoli CM, Young LH, et al. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care 2016; 39:1684.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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