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Are MRAs the Secret Weapon Against Hormonal Hypertension?
Published: Jan 16, 2024
For those battling primary aldosteronism, mineralocorticoid receptor antagonists (MRAs) could be the game-changer in managing blood pressure. Discover how these medications work and who they can help.
The Role of MRAs in Treatment
MRAs like spironolactone and eplerenone are key players in treating primary aldosteronism, especially for those who cannot undergo surgery. These drugs block the effects of aldosterone, helping to regulate blood pressure and potassium levels. They are often the first-line treatment for bilateral adrenal disease.
Choosing Between Spironolactone and Eplerenone
Spironolactone is the go-to choice due to its effectiveness and affordability, but it can cause side effects like breast tenderness. Eplerenone is more selective and has fewer side effects but is generally more expensive. Patients often start with spironolactone and switch to eplerenone if needed.
Monitoring and Adjusting Treatment
Regular monitoring of blood pressure, potassium, and creatinine levels is crucial when using MRAs. Adjustments to dosage may be necessary to achieve optimal results. Monitoring helps avoid potential side effects and ensures the treatment is effective.
Frequently Asked Questions
Drugs that block aldosterone to manage blood pressure.
It's effective, affordable, but may have more side effects.
Blood pressure, potassium, and creatinine levels.
Yes, especially in bilateral adrenal disease or nonsurgical candidates.
The Bottom Line
Could MRAs be the key to controlling your aldosterone-driven hypertension?
References
- Ghose RP, Hall PM, Bravo EL. Medical management of aldosterone-producing adenomas. Ann Intern Med 1999; 131:105.
- Parthasarathy HK, Ménard J, White WB, et al. A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism. J Hypertens 2011; 29:980.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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