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Antithrombin Deficiency: Are You at Risk?
Published: Jun 12, 2024
Antithrombin deficiency can silently increase your risk of blood clots. Knowing whether you're at risk can help you take preventative measures.
What Increases the Risk?
The risk of developing antithrombin deficiency is higher if you have a family history of the condition, as it can be inherited. Other risk factors include liver disease, certain cancer treatments, and being on extracorporeal membrane oxygenation (ECMO). Pregnant women with the condition face an increased risk of blood clots.
How Does It Affect You?
If you have antithrombin deficiency, you are more prone to developing venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism. This condition can be life-threatening if not managed properly. It's important to monitor your health and be aware of symptoms like unexplained swelling or pain in the legs.
Can Lifestyle Influence Risk?
While genetic factors play a major role, lifestyle choices such as smoking, prolonged immobility, and the use of oral contraceptives can further increase the risk of blood clots. Maintaining a healthy lifestyle and managing other health conditions can help mitigate these risks.
Testing and Monitoring
Those with a family history of antithrombin deficiency should consider genetic testing, especially if they plan to start a family. Regular check-ups and blood tests can help monitor antithrombin levels and prevent potential complications.
Frequently Asked Questions
Individuals with a family history, liver disease, or undergoing ECMO are at higher risk.
Yes, factors like smoking and immobility can increase clotting risk.
Yes, especially if there's a family history of thromboembolic events.
Yes, pregnancy increases the risk of clots in those with antithrombin deficiency.
Wrapping Up
Understanding your risk can help you take proactive steps to manage antithrombin deficiency.
References
- Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood 2008; 112:19.
- Loncar R, Kalina U, Stoldt V, et al. Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow. Thromb J 2006; 4:19.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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